Call of Duty 4 the first of the series to stray away from ww2 great game, great story, great graphics, by far a must have title.
Guitar Hero 3, no need to say much about this title.
Mass Effect, action rpg great graphics, deep story line, complete voice over seens, if you love rpgs with out the turn based strategy element you won't want to skip this game.
The orange box: 5 games in one, including all episodes of half life, the portal and team fortress 2.
Assassins Creed, some what over rated but still not to be over looked, first game set in the era, stealth, strategy type, graphics, story, combat, great game.
Ace Combat 6, the first Ace Combat game on a Microsoft console and its exsclusive, great visuals, many plains, with more via xbox live downloadable content, fast paced but easy to pick up and play.
Naruto, the only next gen Naruto game not set in shippuden era but if your a fan of the series you'll appreciate the game.
Saints Row, okay yes GTA4 comes out April.29th and Saint's Row 2 later this year but don't be fooled this game is great and by far the best sandbox game other than gta of course but make your character and take to the streets of still water.
Also Ninja Gaiden Black, Black (FPS) will be availible for download on the 11th of this month, Burnout 3 is there now,
There are many more but these I have actually played and enjoyed every minute, check out www.xbox.com